NUTRITION
Nutritional management of chronic pancreatitis
An overview of the assessment and management of this nutritionally challenging condition
January 1, 2014
-
Chronic pancreatitis (CP) is a progressive inflammatory disease which results in the gradual destruction of pancreatic tissue and progressive exocrine and endocrine dysfunction. The nutritional management of patients with CP tends to be problematic. Issues of concern include vitamin deficiency, osteoporosis, brittle diabetes mellitus (DM) and malabsorption – all of which increase morbidity and affect quality of life (QoL).
Pancreatic exocrine insufficiency
Assessing pancreatic exocrine function
A progressive loss of the exocrine acinar cells in CP results in the reduced production and secretion of pancreatic enzymes, thereby causing nutrient maldigestion and malabsorption (known as pancreatic exocrine insufficiency [PEI]).
Malabsorption of all macronutrients occurs, however fat malabsorption tends to be the most clinically evident. Gross fat malabsorption which results in overt steatorrhoea may only occur in the advanced stages of the disease process.
However, patients may report other symptoms of malabsorption which are less obvious, including bloating, wind, failure to maintain weight, nausea and abdominal pain.
Bloating may be due to the passage of undigested carbohydrate into the colon, where fermentation by the colonic flora results in flatulence and abdominal discomfort.1
Currently, the gold-standard test for measuring pancreatic exocrine function is the faecal elastase-1 (FE-1) test. FE-1 is a human-specific pancreatic enzyme that is not degraded during intestinal transit, is enriched five to sixfold in the faeces, and is therefore a reliable test of exocrine function.2
Pancreatic enzyme replacement therapy (PERT) does not need to be interrupted for testing pancreatic function, nor does the patient have to ingest a specific fat intake for testing, and therefore the FE-1 test is practical in the clinical setting.
A FE-1 level of <100µg/g indicates severe PEI, and 100-200µg/g indicates moderate PEI. Levels should be evaluated in the context of a full clinical assessment.
Pancreatic enzyme replacement therapy
PERT is the mainstay of treatment for PEI3 and treats overt steatorrhoea as well as the less obvious malabsorptive symptoms (bloating, wind, failure to maintain weight, nausea and abdominal pain). It is also a cost-effective4 and safe5,6 therapy.
Several recent randomised controlled trials have demonstrated an increase in fat and nitrogen absorption, improvements in stool frequency, reduced abdominal pain and reduced flatulence for those taking PERT (up to 80,000 units [U] lipase with main meals) compared to a placebo.5,6
Patients with PEI tend to be undertreated, and PERT tends to be under-prescribed.7 It is usually advisable to start with a dose of 40,000-50,000U lipase per meal and 10,000-25,000U lipase per snack,8,9 and to titrate gradually upwards depending on the patient’s response8,9,10 to a maximum dose11 of 10,000U lipase/kg body weight per day.
Acid-suppression medication may also be required8 as pancreatic enzymes are destroyed at a low pH. Regular and detailed dietary assessment is vital to ensure appropriate and adequate PERT usage and to ensure compliance. Intervention by a pancreatic dietitian is considered essential.11,12 Figure 1 details the management of PEI in CP.1