Chronic lymphocytic leukaemia (CLL) is a malignant proliferation of mature B cells, which presents clinically with a circulating peripheral blood lymphocytosis. It is the most common adult leukaemia in the western world and affects males more frequently than females (1.7:1).¹

CLL affects 4.5 per 100,000...

The term congenital bleeding disorders (CBDs) refers to a diverse group of conditions including deficiencies of plasma coagulation factors (such as haemophilia and Von Willebrand disease) and platelet function defects. 

Although management can be complex, the initial presentation of patients with CBDs may be...

Case study 1

A 63-year-old woman presented to her GP with worsening back pain and fatigue

A plain film showed reduced bone density with multiple vertebral compression fractures (see Figure 1).  Her laboratory parameters were significant for a mild normocytic anaemia (Hb 11.5g/dl) and reduced renal...

Case study 1: Staging and indications for therapy and immune mediated cytopenias 

A 29-year-old male presented with a peripheral blood lymphocytosis with anaemia, thrombocytopenia, non-bulky adenopathy and splenomegaly (20cm)

He had a bone marrow aspirate and trephine performed showed replacement of...

Case study 1

A 65-year-old female presents with high white cell count and lymphadenopathy

This patient presented with fatigue, lethargy and loss of appetite for six months. Full blood count showed haemoglobin (HB) 8.3g/dl, white blood cells (WBC) 120 x10^9/L, lymphocyte 90 x10^9/L, platelet 91 x10^9/L....